[HTML][HTML] Cellular functions and molecular mechanisms of ubiquitination in osteosarcoma
J Song, X Yuan, L Piao, J Wang, P Wang… - Frontiers in …, 2022 - frontiersin.org
… PTEN ubiquitination through the E3 ligase CRL4B DCAF13 … As an artificially selected
biological small molecule, … therapy inhibits cancer proliferation and progression by interacting with …
biological small molecule, … therapy inhibits cancer proliferation and progression by interacting with …
CRL4B E3 ligase recruited by PRPF19 inhibits SARS-CoV-2 infection by targeting ORF6 for ubiquitin-dependent degradation
L Zhang, P Hao, X Chen, S Lv, W Gao, C Li, Z Li… - Mbio, 2024 - Am Soc Microbiol
… In this research, we identificated of CUL4B-DDB1-PRPF19 E3 Ubiquitin Ligase … Small
molecule TSC01682 disrupting the CUL4B-DDB1 interaction inhibits osteosarcoma cell growth (50…
molecule TSC01682 disrupting the CUL4B-DDB1 interaction inhibits osteosarcoma cell growth (50…
Protein Stability Regulation in Osteosarcoma: The Ubiquitin-like Modifications and Glycosylation as Mediators of Tumor Growth and as Targets for Therapy
J Di Gregorio, L Di Giuseppe, S Terreri, M Rossi… - Cells, 2024 - mdpi.com
… Small molecule TSC01682 inhibits osteosarcoma cell growth by specifically disrupting
the CUL4B-DDB1 interaction and decreasing the ubiquitination of CRL4B E3 …
the CUL4B-DDB1 interaction and decreasing the ubiquitination of CRL4B E3 …
Cul-4 inhibition rescues spastin levels and reduces defects in hereditary spastic paraplegia models
F Sardina, C Carsetti, L Giorgini, G Fattorini, G Cestra… - Brain, 2024 - academic.oup.com
… their E3 ligase activity, promoting 22 poly-ubiquitination of … as urazole) that inhibits the
interaction between 28 DDB1 and … CRL4 to identify those substrate receptors that work together …
interaction between 28 DDB1 and … CRL4 to identify those substrate receptors that work together …
[HTML][HTML] DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
S Wei, J Xing, J Chen, L Chen, J Lv, X Chen… - Journal of Experimental …, 2024 - Springer
… in the orientation of small molecule drugs, especially in cancer … CRL4B promotes osteosarcoma
cell growth by mediating the … acts as a substrate receptor in CRL4 E3 ligase and binds …
cell growth by mediating the … acts as a substrate receptor in CRL4 E3 ligase and binds …
DCAF13 promotes triple-negative breast cancer metastasis by mediating DTX3 mRNA degradation
J Liu, H Li, A Mao, J Lu, W Liu, J Qie, G Pan - Cell Cycle, 2020 - Taylor & Francis
… Likewise, MSI2a overexpression leads to enhanced interaction … In osteosarcoma cells,
CRL4B-DCAF13 E3 ligase complex … We found that NOTCH4 was a novel ubiquitin substrate of …
CRL4B-DCAF13 E3 ligase complex … We found that NOTCH4 was a novel ubiquitin substrate of …
CRL4B complex promotes the development of pancreatic cancer by inhibiting secreted frizzled related protein 1
Y Chen, S Leng, Y Wang - Zhonghua Zhong liu za zhi [Chinese …, 2021 - europepmc.org
… -RING E3 ubiquitin ligase (CRL4B) complex in pancreatic tumorigenesis and the molecular
… ) in the promoter region of target gene was reduced after CUL4B knockdown. The …
… ) in the promoter region of target gene was reduced after CUL4B knockdown. The …
Neuropilin and tolloid-like 2 regulates the progression of osteosarcoma
X Wang, Z Bian, C Hou, M Li, W Jiang, L Zhu - Gene, 2021 - Elsevier
… gene expression profiling interactive analysis … -knockdown remarkably reduced the expression
of specific mesenchymal … Using LY294002, a specific PI3K inhibitor, we also showed that …
of specific mesenchymal … Using LY294002, a specific PI3K inhibitor, we also showed that …
[HTML][HTML] Construction and validation of a novel eight-gene risk signature to predict the progression and prognosis of bladder cancer
R Wang, Z Zheng, S Mao, W Zhang, J Liu, C Li… - Frontiers in …, 2021 - frontiersin.org
… interact with Cullin4B (CUL4B) to form the CUL4B-DDB1 complex which promotes ubiquitination
and … causes abnormal activation of NF-κB pathway thereby inhibiting cancer (25, 26). …
and … causes abnormal activation of NF-κB pathway thereby inhibiting cancer (25, 26). …